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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus typeI (HIV-1).This observation indicates that the immune responses elicited by natural HIV-1 infection may play a roleThus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanand if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 136-148 doi: 10.1007/s11684-020-0756-y

Abstract: Precise identification of HIV transmission among populations is a key step in public health responses. However, the HIV transmission network is usually difficult to determine. HIV molecular networks can be determined by phylogenetic approach, genetic distance-based approach, and a combination of both approaches. These approaches are increasingly used to identify transmission networks among populations, reconstruct the history of HIV spread, monitor the dynamics of HIV transmission, guide targeted intervention on key subpopulations, and assess the effects of interventions. Simulation and retrospective studies have demonstrated that these molecular network-based interventions are more cost-effective than random or traditional interventions. However, we still need to address several challenges to improve the practice of molecular network-guided targeting interventions to finally end the HIV epidemic. The data remain limited or difficult to obtain, and more automatic real-time tools are required. In addition, molecular and social networks must be combined, and technical parameters and ethnic issues warrant further studies.

Keywords： human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention    

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Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 346-350 doi: 10.1007/s11684-010-0102-x

Abstract: FPDs all have an approximate time of human immunodeficiency virus (HIV) infection during the mid-1990sA retrospective cohort study was conducted based on data collected from 5484 HIV-1 infected FPDs in Shangcai

Keywords： human immunodeficiency virus (HIV)     former plasma donor     natural history     China    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseases

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelial    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 471-479 doi: 10.1007/s11684-017-0602-z

Abstract:

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutininTypically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with littleSimilarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directedHere we review what is known about the human humoral immune response to vaccination and infection withunderstanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus

Keywords： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip Article

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Engineering 2015, Volume 1, Issue 3,   Pages 324-335 doi: 10.15302/J-ENG-2015072

Abstract:

Viral load measurements are an essential tool for the long-term clinical care of human immunodeficiencyvirus (HIV)-positive individuals.

Keywords： human immunodeficiency virus (HIV)     viral load     loop-mediated isothermal amplification     smartphone     point-of-care    

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Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 4-13 doi: 10.1007/s11684-013-0248-4

Abstract: This review summarizes the current findings of metabolomic studies in human investigations with the mostcommon form of diabetes, type 2 diabetes.

Keywords： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 1-5 doi: 10.1007/s11684-014-0309-3

Abstract: We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing

Keywords： hyperthermia     HPV     immune response     virus     tumor    

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 459-462 doi: 10.1007/s11684-009-0084-8

Abstract: The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in women

Keywords： cervical cancer     human papilloma virus     cervical intraepithelial neoplasia    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction withhepatitis B virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract: designed to investigate the contribution of miRNA-122-binding site polymorphism at the IL-1A gene and its multiplicative interactions with hepatitis B virus (HBV) mutations in the riskThis study provides an insight into the complex host-virus interaction in HBV-induced hepatocarcinogenesis

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 147-156 doi: 10.1007/s11684-010-0030-9

Abstract: The pandemic H1N1 2009 influenza virus has caused the first influenza pandemic of the 21st century, leading

Keywords： influenza A virus     H1N1 subtype     pandemic     pathogenesis     virulence factors     immunity     management     antiviral    

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 462-470 doi: 10.1007/s11684-017-0596-6

Abstract: syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virusWe also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebolavirus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral

Keywords： human monoclonal antibodies     emerging infectious diseases     SARS-CoV     MERS-CoV     Ebola virus    

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Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 399-411 doi: 10.1007/s11684-010-0170-y

Abstract: in the development of hepatocellular carcinoma (HCC), β-catenin was correlated with hepatitis B virusThe expression levels of wild-type β-catenin and E-cadherin were decreased in HepG2 cells expressinghepatitis B virus X protein (HBx), accompanied by destabilization of adherens junction.Reverse transcriptase PCR (RT-PCR), Northern and Western blot showed that reduction of wild-type βsuggest that the expression of HBx contributed to the development of HCC, in part, by repressing the wild-type

Keywords： hepatocellular carcinoma     hepatitis B virus X protein     β     -catenin     cell adhesion     E-cadherin     transcriptional    

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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: antiretroviral therapy (cART) has significantly improved the life expectancy of people living with humanimmunodeficiency virus (HIV), but it has many side effects such as lipodystrophy (LD), hepatic steatosisNucleoside reverse transcriptase inhibitors (NRTIs) could damage the mitochondria by inhibiting the human

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 933-937 doi: 10.1007/s11684-021-0860-7

Abstract: Neurofibromatosis (NF) is a genetic disease in which the lungs are rarely involved. However, in NF cases with lung involvement, chest computed tomography may show bilateral basal reticulations, apical bullae, and cysts without bronchiectasis. Herein, we report a patient diagnosed with NF on the basis of the results of genetic testing who presented with early-onset wet cough and bronchiectasis. Considering the differential diagnosis of bronchiectasis combined with his early-onset wet cough, sinusitis, and sperm quality decline, we considered the possibility of primary ciliary dyskinesia (PCD). Further electron microscopy analysis of cilia and identification of homozygous mutations in the RSPH4A gene confirmed the diagnosis of PCD. Therefore, for patients with NF, when an image change exists in the lungs that does not correspond to NF, the possibility of other diagnoses, including PCD, must be considered.

Keywords： primary ciliary dyskinesia     neurofibromatosis     bronchiectasis     transmission electron microscopy     genetic sequencing    

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Title Author Date Type Operation

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Journal Article

Natural history of HIV infection in former plasma donors in rural China

Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

Daniel Stadlbauer, Raffael Nachbagauer, Philip Meade, Florian Krammer

Journal Article

Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip

Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir

Journal Article

Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

Xinghua Gao, Hongduo Chen

Journal Article

Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction withhepatitis B virus mutations with hepatocellular carcinoma risk

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article

Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management

Kelvin Kai-Wang TO FRCPath, Iris Wai-Sum LI FRCP, Ivan Fan-Ngai HUNG FRCP, Vincent Chi-Chung CHENG FRCPath, Kwok-Yung YUEN MD,

Journal Article

Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Journal Article

Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas

Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,

Journal Article

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

Case report of neurofibromatosis type 1 combined with primary ciliary dyskinesia

Journal Article